The Raspberry Pi 4 is finally here and has a lot of exciting changes. One very major downside is that it doesn’t support true USB booting yet out of the box (like the 3 series did). The Raspberry Pi foundation states that it is being worked on and will be added back with a future update. No timeline has been given yet for that to happen but they state it’s one of their top priorities.

Source: Raspberry Pi 4 USB Boot Config Guide for SSD / Flash Drives