20 years working on the same software product | Successful Software
I now divide my time between PerfectTablePlan and my 2 other products: data wrangling software Easy Data Transform and visual planner Hyper Plan. Having multiple products keeps things varied and avoids having all my eggs in one basket. In May 2024 I released PerfectTablePlan v7 with a load of improvements and new features. And I […]
LukeW | Molecular Sequence Modeling & Design
Evo 2 excels at predicting the effects of mutations on human genes, particularly in non-coding regions where current models struggle. When fine-tuned on known breast cancer mutations, it achieves state-of-the-art performance. Source: LukeW | Molecular Sequence Modeling & Design
Paths through the space of all possible solutions | sean goedecke
Some engineers seem like they’re moving through the world like magic. Everything they touch looks easy, they never get blocked by anything, and they end up shipping a lot without much heartache. These are almost always engineers who are deeply familiar with the space of possible solutions at the company they work at, and who […]
Shadow IT, shadow research, and democratizing research | go ahead, mac my day
When a research team tries to clamp down on research activities by others, unless that team is incredibly well-resourced and well-supported, with enough visibility that everyone knows where to go to get great research, shadow research happens. People who want to talk to users/customers will find a way whether the research team wants them to […]
Michael Tsai – Blog – One Year With the Vision Pro
A year on, I can’t in good conscience recommend that anyone buy one. It’s a glimpse of a potential future and a developer kit for potential future Apple platforms, but that’s about it. Source: Michael Tsai – Blog – One Year With the Vision Pro
Ollama – NSHipster
Building macOS Apps with Ollama Source: Ollama – NSHipster Mattt is back!
关于推理模型的一些误解和盲区 | OneV’s Den
最常见的一个现象，就是大家都倾向于无脑点上“深度思考 (R1)”。其实这个行为有待商榷。 Source: 关于推理模型的一些误解和盲区 | OneV’s Den
It’s All One Bubble – David Cahn’s Substack
Building on the writing of five different thinkers, I will explain how the Dot-com bubble, the 2008 financial crisis, the 2021 tech bubble, and our current bubble (whatever it ends up being called), can be viewed as one, big bubble. Source: It’s All One Bubble – David Cahn’s Substack
Daring Fireball: OpenAI’s Board, Paraphrased: ‘To Succeed, All We Need Is Unimaginable Sums of Money’
effectively, OpenAI is to this decade’s generative-AI revolution what Netscape was to the 1990s’ internet revolution. The revolution is real, but it’s ultimately going to be a commodity technology layer, not the foundation of a defensible proprietary moat. In 1995, investors mistakenly thought investing in Netscape was a good way to bet on the future […]
DeepSeek jailbreak
By prompting DeepSeek to converse with me using exclusively these charcodes, I could effectively bypass the filter. Source: Home | Substack